Chemistry and Biochemistry

David V. Dearden

David Dearden

Office: C104B BNSN
Office Phone: 801-422-2355
Lab Room: C354 and C370 BNSN
Lab Phone: 801-422-5383
Office Hours


BS, Brigham Young University (1983)

Ph.D., California Institute of Technology (1989)

NRC Postdoctoral Fellow, U.S. National Institute of Standards and Technology (1989-90)

NSF Young Investigator (1993-98)

Curriculum Vitae


The Dearden group’s research centers on the development and use of state-of-the-art, extremely sensitive chemical analysis tools. The instrument we work with, a Fourier transform mass spectrometer (FTMS), weighs molecules with accuracies of about one part per million, and can distinguish between molecules with similar weights better than any other available technique. With this kind of accuracy, merely weighing a molecule is usually enough to unambiguously identify it, and this can be done with samples whose total mass is less than one billionth of a gram. Further, because the instrument “levitates” and traps molecules in a strong magnetic field, it serves as a sophisticated “test tube” in which we can carry out and study complex reactions with these tiny quantities of material. Read more


"Collision Cross Sections for 20 Protonated Amino Acids: Fourier Transform Ion Cyclotron Resonance and Ion Mobility Results." Anupriya; Jones, C. A.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2016, 27, 1366-1375. doi: 10.1007/s13361-016-1409-x. 

“Isotopic Compositions and Exact Masses of Single Isotopic Peaks,” Rockwood, A. L.; Van Orman, J. R.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2004, 15, 12-21.

“Sonic Spray Ionization Mass Spectrometry: A Powerful Tool Used to Characterize Fragile Metal-Assembled Cages,” Gardner, J. S.; Harrison, R. G.; Lamb, J. D.; Dearden, D. V. New J. Chem. 2006, 30, 1276-1282.

“Molecular Beads on a Charged Molecular String: a,.-Alkyldiammonium Complexes of Cucurbit[6]uril in the Gas Phase,” Zhang, H.; Ferrell, T. A.; Asplund, M. C.; Dearden, D. V. Int. J. Mass Spectrom. 2007, 265, 187-196.

“One Ring to Bind Them All: Shape-Selective Complexation of Phenylenediamine Isomers with Cucurbit[6]uril in the Gas Phase,” Dearden, D. V.; Ferrell, T. A.; Asplund, M. C.; Zilch, L. W.; Julian, R. R.; Jarrold, M. F. J. Phys. Chem. A 2009, 113, 989-997.

“Supramolecular Modification of Ion Chemistry: Modulation of Peptide Charge State andDissociation Behavior through Complexation with Cucurbit[n]uril (n = 5,6) or a-Cyclodextrin,” Zhang, H.; Grabenauer, M.; Bowers, M. T.; Dearden, D. V. J. Phys. Chem. A 2009, 113, 15081517.

“Equilibrium Methods for Characterizing Gas Phase Chiral Recognition,” Dearden, David. V.; Fang, Nannan. Book chapter submitted 1 Apr 2009 for Taylor & Francis book on gas phase chiral recognition. Anne Zehnacker, editor.

“Collision Cross Sectional Areas by Fourier Transform Ion Cyclotron Resonance (CRAFTI): aNew Method for Characterizing Molecular Structure,” Yang, F.; Voelkel, J. E.; Dearden, D. V. Anal. Chem. in preparation.

See complete publication list