Chemistry and Biochemistry



Organic chemists are interested in organic molecules of many different types. They may synthesize these compounds in the laboratory or isolate them from natural sources. Many of the molecules that organic chemists study play important roles in biology and medicine.

Related Faculty

Merritt B. Andrus


Efforts in our lab are focused on methods for the synthesis of biologically active natural products that possess unique structures and potential for combinatorial library construction and screening. New methods include metal catalyzed couplings and condensations to assemble key intermediates. Libraries of structural variants are then made and used to probe receptor binding and improve activity. Recent work includes the ...

Read more

Steven L. Castle


Castle Research Group Our research is focused on the total synthesis of architecturally complex bioactive natural products and peptides. We believe that the structures of such compounds can serve as inspiration for the invention of new organic reactions and processes. Additionally, studies of their biological activity can increase our understanding of their modes of action, potentially leading to the design ...

Read more

Daniel H. Ess


Ess Research Group My group utilizes and develops quantum-chemistry methods to discover mechanisms, reactivity principles, and selectivity for experimentally important chemical reactions related to catalysis, energy, and organic synthesis. My group emphasizes both quantitative modeling and the development of qualitative models that can be used to make experimental predictions. This naturally leads to close collaboration with experimental groups. My group ...

Read more

David J. Michaelis


Michaelis Research Group A multidisciplinary approach to science can enable advances not only at the interface of two fields, but also within strictly disciplinary research. This capacity derives from an acquired understanding of the scientific approach, methods, and techniques used in other disciplines to solve problems. I intend to establish a research program that employs tools and techniques from other ...

Read more

Matt A. Peterson


Research in our group focuses on the chemical synthesis and biological evaluation of potential antitumor and/or antiviral compounds. Modification of naturally occurring nucleosides is a unifying feature in our research. Current interests can be broken down into three areas: (1) Synthesis and evaluation of nucleoside-based enediynes (e.g., uracil-fused and uracil-linked enediynes I and II; and adenosine mimic III); (2) Synthesis ...

Read more

Joshua L. Price


Research interests include: Bioorganic chemistry Protein folding and structure The structural and energetic effects of protein glycosylation Design of novel proteins using unnatural amino acids

Read more

Paul B. Savage


Membrane active antibiotics Glycolipid immunology Our research is primarily in two areas. We have developed small-molecule mimics of antimicrobial peptides, and we are working to understand better their mechanism of antibacterial activity, optimize medical device coatings containing these mimics to prevent bacterial colonization, and optimizing compound structures for varied applications. We also work with immunostimulatory glycolipids and oligosaccharide vaccines.

Read more

View all chemistry faculty