Dr. Simmons steps down after 17 years as the director of the center. Dr. Steven L. Castle, also from the Department of Chemistry and Biochemistry, will be the center's new associate director.
Dr. Michaelis' lab is developing "assembly-line chemical synthesis" using processes found in nature.
Dr. Daniel Ess featured in the news for his study on natural gas.
Professor Daniel Ess and colleagues earned the front cover of the Journal of the American Chemical Society (JACS) for their research on biaryl structural motifs.
Organic chemists are interested in organic molecules of many different types. They may synthesize these compounds in the laboratory or isolate them from natural sources. Many of the molecules that organic chemists study play important roles in biology and medicine.
Efforts in our lab are focused on methods for the synthesis of biologically active natural products that possess unique structures and potential for combinatorial library construction and screening. New methods include metal catalyzed couplings and condensations to assemble key intermediates. Libraries of structural variants are then made and used to probe receptor binding and improve activity. Recent work includes the ...
Castle Research Group Our research is focused on the total synthesis of architecturally complex bioactive natural products and peptides. We believe that the structures of such compounds can serve as inspiration for the invention of new organic reactions and processes. Additionally, studies of their biological activity can increase our understanding of their modes of action, potentially leading to the design ...
Ess Research Group My group utilizes and develops quantum-chemistry methods to discover mechanisms, reactivity principles, and selectivity for experimentally important chemical reactions related to catalysis, energy, and organic synthesis. My group emphasizes both quantitative modeling and the development of qualitative models that can be used to make experimental predictions. This naturally leads to close collaboration with experimental groups. My group ...
Michaelis Research Group A multidisciplinary approach to science can enable advances not only at the interface of two fields, but also within strictly disciplinary research. This capacity derives from an acquired understanding of the scientific approach, methods, and techniques used in other disciplines to solve problems. I intend to establish a research program that employs tools and techniques from other ...
Research in our group focuses on the chemical synthesis and biological evaluation of potential antitumor and/or antiviral compounds. Modification of naturally occurring nucleosides is a unifying feature in our research. Current interests can be broken down into three areas: (1) Synthesis and evaluation of nucleoside-based enediynes (e.g., uracil-fused and uracil-linked enediynes I and II; and adenosine mimic III); (2) Synthesis ...
Research interests include: Bioorganic chemistry Protein folding and structure The structural and energetic effects of protein glycosylation Design of novel proteins using unnatural amino acids
Membrane active antibiotics Glycolipid immunology Our research is primarily in two areas. We have developed small-molecule mimics of antimicrobial peptides, and we are working to understand better their mechanism of antibacterial activity, optimize medical device coatings containing these mimics to prevent bacterial colonization, and optimizing compound structures for varied applications. We also work with immunostimulatory glycolipids and oligosaccharide vaccines.