Adam T Woolley
C104C BNSN
801-422-1701
801-422-1397
BS, Brigham Young University (1992)
Ph.D., University of California, Berkeley (1997)
Runyon-Winchell Postdoctoral Fellow, Harvard University (1998-2000)
Analytical Chemistry
Additional research areas: Bioanalytical, Chromatography/Electrophoresis, Materials and Surfaces
My group works at the interface between chemistry, engineering and biology. Thus, students receive broad technical training and are well poised to contribute in these key research fields. A common theme in my research is the interrelationship between biological molecules and miniaturization. We are utilizing miniaturization tools to detect and quantify clinically relevant biomolecules, and we are also applying biological molecules (in particular DNA) in forming nanoscale integrated circuits. To read more click here.
Selected publications:
Yang, W.; Yu, M.; Sun, X.; Woolley, A.T. Microdevices Integrating Affinity Columns and Capillary Electrophoresis for Multi-biomarker Analysis in Human Serum. Lab Chip 10, 2527–2533 (2010).
Hamblin, M.N., Xuan, J., Maynes, D., Tolley, H.D., Belnap, D.M., Woolley, A.T., Lee, M.L., Hawkins, A.R.; Lab Chip,2010, 10, 173-178. Selective trapping and concentration of nanoparticles and viruses in dual-height nanofluidic channels.
Ming, Y., Hsiang-Yu, W., Woolley, A.T.; Electrophoresis, 2009, 4230-4236. Polymer microchip CE of proteins either off- or on-chip labeled with chameleon dye for simplified analysis.
Pound, E.; Ashton, J.R.; Becerril, H.A.; Woolley, A.T.; Nano Letters, 2009, 9, 12, 4302-4305. Polymerase Chain Reaction Based Scaffold Preparation for the Production of thin, Branches DNA Origami Nanostructures of Arbitrary Sizes.
Pound, E.; Ashton, J.R.; Becerril, H.A.; Woolley, A.T. PCR-based Scaffold Preparation for the Production of Thin, Branched DNA Origami Nanostructures of Arbitrary Sizes. Nano Lett. 9, 4302-4305 (2009).
Yang, W.; Sun, X.; Wang, H.-Y.; Woolley, A.T. Integrated Microfluidic Device for Serum Biomarker Quantitation using Either Standard Addition or a Calibration Curve. Anal. Chem. 81, 8230-8235 (2009).
Becerril, H.A.; Woolley, A.T. DNA-Templated Nanofabrication. Chem. Soc. Rev. 38, 329-337 (2009).
Sun, X.; Yang, W.; Pan, T.; Woolley, A.T. Affinity Monolith-Integrated Poly(methyl Methacrylate) Microchips for On-Line Protein Extraction and Capillary Electrophoresis. Anal. Chem. 80, 5126-5130 (2008).
Yang, W.; Sun, X.; Pan, T.; Woolley, A.T. Affinity Monolith Preconcentrators for Polymer Microchip Capillary Electrophoresis. Electrophoresis 29, 3429-3435 (2008).
Peeni, B.A.; Lee, M.L.; Hawkins, A.R.; Woolley, A.T. Sacrificial Layer Microfluidic Device Fabrication Methods. Electrophoresis 27, 4888-4895 (2006).
Kelly, R.T.; Li, Y.; Woolley, A.T. Phase-Changing Sacrificial Materials for Interfacing Microfluidics with Ion-Permeable Membranes To Create On-Chip Preconcentrators and Electric Field Gradient Focusing Microchips. Anal. Chem. 78, 2565-2570 (2006).
Kelly, R.T.; Pan, T.; Woolley, A.T. Phase-Changing Sacrificial Materials for Solvent Bonding of High-Performance Polymeric Capillary Electrophoresis Microchips. Anal. Chem. 77, 3536-3541 (2005).
Becerril, H.A.; Stoltenberg, R.M.; Wheeler, D.R.; Davis, R.C.; Harb, J.N.; Woolley, A.T. DNA-Templated Three-Branched Nanostructures for Nanoelectronic Devices. J. Am. Chem. Soc. 127, 2828-2829 (2005).
Xin, H.; Woolley, A.T. DNA-Templated Nanotube Localization. J. Am. Chem. Soc. 125, 8710-8711 (2003).
Monson, C.F.; Woolley, A.T. DNA-Templated Construction of Copper Nanowires. Nano Lett. 3, 359-363 (2003).