Chemistry Department

View
Track

Matt A Peterson

Address:

Department of Chemistry and Biochemistry
Brigham Young University
Provo, UT 84602

Office Hours

Office: C463 BNSN

Office Phone: 801-422-6843

Lab Phone: 801-422-7326

Education Information:

BS (Chemistry), Utah State University (1987)

BS (Biology), Utah State University (1987)

Ph.D., University of Arizona (1992)

NIH Postdoctoral Fellow, Colorado State University (1993-94)

Organic Chemistry

Research in our group focuses on the chemical synthesis and biological evaluation of potential antitumor and/or antiviral compounds. Modification of naturally occurring nucleosides is a unifying feature in our research. Current interests can be broken down into three areas: (1) Synthesis and evaluation of nucleoside-based enediynes (e.g., uracil-fused and uracil-linked enediynes I and II; and adenosine mimic III); (2) Synthesis and evaluation of transition-state analogue inhibitors of key enzymes involved in the pyrimidine-nucleoside manifold (e.g., potential cytidine triphosphate synthetase and cytidine deaminase inhibitors typified by structure IV), and (3) Synthesis and evaluation of inhibitors of HIV integrase. Visit this page to learn more.

Publications:

Selected Publications

J. R. Shelton, Scott R. Burt, and M. A. Peterson "A Broad Spectrum Anticancer Nucleoside with Selective Toxicity Against Human Colon Cancer Cells in Vitro" Bioorg. Med. Chem. Lett. 21, 1484–1487 (2011).
M. A. Peterson, M. Oliveira, M. A. Christiansen, and C. E. Cutler “Preliminary SAR Analysis of Novel Antiproliferative N⁶,5'-Bis-ureidoadenosine Derivatives” Bioorg. Med. Chem. Lett. 19, 6775–6779 (2009).
M. J. Robins, H. Yang, K. Miranda, M. A. Peterson, E. DeClercq, and J. Balzarini “Synthesis and Biological Evaluation of 3,3-Difluoropyridine-2,4(1H,3H)-dione and 3-Deaza-3-fluorouracil Base and Nucleoside Derivatives,” J. Med. Chem. 52, 3018–3027 (2009).
M. A. Peterson, M. Oliveira, M. A. Christiansen “Antiproliferative and Protein Kinase Binding Activities of Some N⁶,5'-Bis-ureido 5'-Amino-5'-deoxyadenosine Derivatives” Nucleos. Nucleot. Nucl. 28, 394–407 (2009).
M. J. Robins, V. K. Rajwanshi, K. Miranda, M. A Peterson, E. DeClercq, and J. Balzarini, "Synthesis and Antiviral Evaluation of 6-[Alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one Nucleosides and Analogues with Ethynyl, Ethenyl, and Ethyl Spacers at C6 of the Furopyrimidine Core" J. Med. Chem. 50, 3897–3905 (2007).
M. A. Peterson, P. Ke, H. Shi, B. R. McDougal, and E. W. Robinson, Jr. "Design, Synthesis, and Antiviral Evaluation of Some 3'-Carboxymethyl-3'-deoxyadenosine Derivatives" Nucleos. Nucleot. Nucl. 26, 499–519 (2007).
M. A Peterson, H. Shi, P. Ke "A Simple and Efficient Biphasic Method for the Preparation of 4-Nitrophenyl N-Methyl- and N-Alkylcarbamates" Tetrahedron Lett. 47, 3405–3407 (2006).
M. J. Robins, K. Miranda, V. K. Rajwanshi, M. A Peterson, G. Andrei, R. Snoeck, E. De Clercq, and J. Balzarini, "Synthesis and Biological Evaluation of 6-(Alkyn-1-yl) furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives" J. Med. Chem. 49, 391–398 (2006).
Z. Zhao, D. Gubler, J. Peacock, and M. A. Peterson, "Photoinduced Bergman Cycloaromatization of Imidazole-Fused Enediynes" Tetrahedron Lett. 46, 1373–1375 (2005).
Z. Zhao, Y. Peng, N.K. Dalley, J.F. Cannon, and M.A. Peterson, “Bergman Cycloaromatization of Imidazole-Fused Enediynes: The Remarkable Effect of N-Aryl Substitution,” Tetrahedron Lett. 45, 3621-3624 (2004).
E. S. Kumarasinghe, M. A. Peterson, and M. J. Robins, “Synthesis of 5, 6-bis (alkyn-1-yl) Pyrimidines and Related Nucleosides,” Tetrahedron Lett., 41, 8741-8745 (2000).