Additional research areas: Bioanalytical, Environmental, Capillary Chromatography and Electrophoresis, Mass Spectrometry, Microfluidics, Microseparation Techniques, Monolithic Stationary Phases and Hand-portable GC-MS
Fast and accurate chemical analysis methods are required to support current biomedical, pharmaceutical, clinical, environmental, and anti-terrorism activities. The ultimate goal is to develop sophisticated and, in many cases, miniaturized instrumentation that can be used to interrogate a sample with sufficient selectivity, sensitivity, and speed to provide reliable qualitative and quantitative information in near real-time. Read more
Y. Li, H.D. Tolley, M.L. Lee, “Preparation of Monoliths from Single Crosslinking Monomers for Reversed-Phase Capillary Chromatography of Small Molecules,” J. Chromatogr. A, 1218, 1399-1408 (2011).
A.N. Nackos, T.V. Truong. T.C. Pulsipher, J.A. Kimball, H.D. Tolley, R.A. Robison, C.H. Bartholomew, M.L. Lee, “One-Step Conversion of Dipicolinic Acid to its Dimethyl Ester Using Monomethyl Sulfate Salts for GC-MS Detection of Bacterial Endospores,” Anal. Methods 3, 245-258 (2011).
Y. Li, H.D. Tolley, M.L. Lee, “Size-Exclusion Separation of Proteins Using a Biocompatible Polymeric Monolithic Capillary Column with Mesoporosity,” J. Chromatogr. A, 1217, 8181-8185 (2010).
Y. Li, H.D. Tolley, M.L. Lee, “Monoliths from Poly(ethylene glycol) Diacrylate and Dimethacrylate for Capillary Hydrophobic Interaction Chromatography of Proteins,” J. Chromatogr. A1217, 4934-4945 (2010).
T.V. Truong, A.N. Nackos, J.R. Williams, D.N. VanDerwerken, J.A. Kimball, J.A. Murray, J.E. Hawkes, D.J. Harvey, H.D. Tolley, R.A. Robison, C.H. Bartholomew, M.L. Lee, “Differentiation of Bacillus Endospore Species from Fatty Acid Methyl Ester Biomarkers,” Anal. Methods 2, 638-644 (2010).
M.N. Hamblin, J. Xuan, D. Maynes, H.D. Tolley, D.M. Belnap, A.T. Woolley, M.L. Lee, A.R. Hawkins, “Selective Trapping and Concentration of Nanoparticles and Viruses in Dual-height Nanofluidic Channels,” Lab Chip 10, 173-178 (2010).
X. Chen, H.D. Tolley, M.L. Lee, “Polymeric Cation-exchange Monolithic Columns Containing Phosphoric Acid Functional Groups for Capillary Liquid Chromatography of Peptides and Proteins,” J. Chromatogr. A 1217, 3844-3854 (2010).

