Chemistry Department

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Paul B Savage

Address:

Department of Chemistry and Biochemistry
Brigham Young University
Provo, UT 84602

Office Hours

Office: C104C BNSN

Office Phone: 801-422-4020

Lab Phone: 801-422-4172

Education Information:

BS, Brigham Young University (1988)

Ph.D., The University of Wisconsin (1993)

Postdoctoral Research, Ohio State University (1993-1995)

Curriculum Vitae:

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PBS CV.docx

Organic Chemistry

Research interests include:

Membrane active antibiotics
Glycolipid immunology

Our research is primarily in two areas. We have developed small-molecule mimics of antimicrobial peptides, and we are working to understand better their mechanism of antibacterial activity, optimize medical device coatings containing these mimics to prevent bacterial colonization, and optimizing compound structures for varied applications. We also work with immunostimulatory glycolipids and oligosaccharide vaccines.

Research Group

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Publications:

Scanlon, S.; Thomas, S.; Ferreira, C. M.; Bai, L.; Krausz, T.; Savage, P. B.; Bendelac, A. J. Exp. Med. 2011, 208, 2113-2124. Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation.

Deng, S.; Mattner, J.; Zang, Z.; Bai, L.; Teyton, L.; Bendelac, A.; Savage, P. B. Org. Biomol. Chem. 2011, 9, 7659-7662. Impact of sugar stereochemistry on natural killer T Cell stimulation by bacterial glycolipids.

Epand, R. F.; Pollard, J. E.; Wright, J. O.; Savage, P. B.; Epand, R. M. Antimicrob. Agents Chemother. 2010, 54, 3708-3717. Depolarization, bacterial membrane composition and the antimicrobial action of ceragenins.

Yin, N.; Long, X.; Goff, R. D.; Zhou, D.; Cantu, C.; Mattner, J.; Saint Mezard, P.; Teyton, L.; Bendelac, L.; Savage, P. B. ACS Chem. Biol. 2009, 4, 191-197. Alpha anomers of iGb3 and Gb3 stimulate cyotkine production by natural killer T cells. PMCID: PMC2843501

Lai, X.-Z.; Feng, Y.; Pollard, J.; Chin, J. N.; Rybak, M. J.; Bucki, R.; Epand, R. F.; Epand, R. M.; Savage, P. B. Acc. Chem. Res. 2008, 41, 1233-1240. Ceragenins: cholic acid-based mimics of antimicrobial peptides.

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Awards

Brigham Young University Karl G. Maeser Research and Creative Arts Award, 2006
Stoel Rives Utah Innovation Award, Biotechnology, 2006
Brigham Young University Technology Transfer Award, 2005
Brigham Young University Karl G. Maeser Excellence in Teaching Award, 2004
Brigham Young University Creative Works Award, 2001
Brigham Young University Young Scholar Award, 2000
College of Physical and Mathematical Sciences Award for Excellence in Teaching, 1999
National Science Foundation CAREER Award, 1998 - 2002
Student Award for Excellence in Teaching-Department of Chemistry, 1998
Student Award for Excellence in Teaching-Department of Chemistry, 1997