Chemistry and Biochemistry

David V. Dearden

David Dearden

Office: C104B BNSN
Office Phone: 801-422-2355
Lab Room: C354 BNSN, C370 BNSN
Lab Phone: 801-422-5383
Office Hours


BS, Brigham Young University (1983)

Ph.D., California Institute of Technology (1989)

NRC Postdoctoral Fellow, U.S. National Institute of Standards and Technology (1989-90)

NSF Young Investigator (1993-98)

Curriculum Vitae


The Dearden Group’s research centers on the development and use of state-of-the-art, extremely sensitive chemical analysis tools.

The Group primarily works with a Fourier transform mass spectrometer (FTMS), which weighs molecules with accuracies of about one part per million and can distinguish between molecules with similar weights better than any other available technique. With the FTMS's kind of accuracy, merely weighing a molecule is usually enough to unambiguously identify it, and this can be done with samples whose total mass is less than one billionth of a gram. Further, because the instrument “levitates” and traps molecules in a strong magnetic field, it serves as a sophisticated “test tube” in which we can carry out and study complex reactions with these tiny quantities of material. 


“One Ring to Bind Them All: Shape-Selective Complexation of Phenylenediamine Isomers
with Cucurbit[6]uril in the Gas Phase,” Dearden, D. V.; Ferrell, T. A.; Asplund, M. C.; Zilch,
L. W.; Julian, R. R.; Jarrold, M. F. J. Phys. Chem. A 2009, 113, 989-997.

"Supramolecular Modification of Ion Chemistry: Modulation of Peptide Charge State and Dissociation Behavior through Complexation with Cucurbit[n]uril (n = 5,6) or Alpha-
Cyclodextrin,” Zhang, H.; Grabenauer, M.; Bowers, M. T.; Dearden, D. V. J. Phys. Chem. A
2009, 113, 1508-1517.

“Influence of charge repulsion on binding strengths: experimental and computational
characterization of mixed alkali metal complexes of decamethylcucurbit[5]uril,” Mortensen,
D. N.; Dearden, D. V. Chem. Commun. 2011, 47, 6081-6083.

“Collision Cross Sectional Areas from Analysis of Fourier Transform Ion Cyclotron
Resonance Line Width: a New Method for Characterizing Molecular Structure,” Yang, F.;
Voelkel, J. E.; Dearden, D. V. Anal. Chem. 2012, 84, 4851-4857.

"Binding of a,w-Alkyldiammonium Ions by Cucurbit[n]urils in the Gas Phase," Yang, F.; Jones, C. A.; Selvapalam, N.; Ko, Y. H.; Kim, K.; Dearden, D. V. Supramol. Chem. 2014, 26, 684-691. 


"Linewidth Pressure Measurement: a New Technique for High Vacuum Characterization," Jones, C. A.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2015, 26, 323-329. doi:10.1007/s13361-014-1031-8. 


"Collision Cross Sections for 20 Protonated Amino Acids: Fourier Transform Ion Cyclotron Resonance and Ion Mobility Results." Anupriya; Jones, C. A.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2016, 27, 1366-1375. doi: 10.1007/s13361-016-1409-x.

 "Quantitative Collision Cross-Sections from FTICR Linewidth Measurments: Improvements in Theory and Experiment," Anupriya; Gustafson, E.; Mortensen, D. N.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2017, in press. doi: 10.1007/s13361-017-1738-4.


See complete publication list