Chemistry and Biochemistry

David V. Dearden

David Dearden

Office: C307 BNSN
Office Phone: 801-422-2355
Lab Room: C354 BNSN, C370 BNSN
Lab Phone: 801-422-5383
Email: dvd@chem.byu.edu
Office Hours

Education:

BS, Brigham Young University (1983)

Ph.D., California Institute of Technology (1989)

NRC Postdoctoral Fellow, U.S. National Institute of Standards and Technology (1989-90)

NSF Young Investigator (1993-98)

Curriculum Vitae

Research:

The Dearden Group’s research centers on the development and use of state-of-the-art, extremely sensitive chemical analysis tools.

The Group primarily works with a Fourier transform mass spectrometer (FTMS), which weighs molecules with accuracies of about one part per million and can distinguish between molecules with similar weights better than any other available technique. With the FTMS's kind of accuracy, merely weighing a molecule is usually enough to unambiguously identify it, and this can be done with samples whose total mass is less than one billionth of a gram. Further, because the instrument “levitates” and traps molecules in a strong magnetic field, it serves as a sophisticated “test tube” in which we can carry out and study complex reactions with these tiny quantities of material. 

Publications:

“Ion Mobility and Fourier Transform Ion Cyclotron Resonance Collision Cross-section Techniques Yield Long-Range and Hard-Sphere Results, Respectively,” Heravi, Tina; Arslanian, Andrew J.; Johnson, Spencer; Porter, Savannah R.; Dearden, David V. J. Am. Soc. Mass Spectrom. 2022, 33 (9), 1644-1652. DOI: 10.1021/jasms.2c00112.

“Collision Cross-section Measurements of Collision-induced Dissociation Precursor and Product Ions in an FTICR-MS and an IM-MS: A Comparative Study,” Arslanian, Andrew J.; Mismash, Noah; Dearden, David V. J. Am. Soc. Mass Spectrom. 2022, 33 (9), 1626-1635. DOI: 10.1021/jasms.2c00089. DOI: 10.1021/jasms.2c00089.

“Prototypical Allosterism in a Simple Ditopic Ligand: Gas Phase Topologies of Cucurbit[n]uril•n- Alkylammonium Complexes Controlled by Binding in the Second Site,” Shrestha, Jamir; Porter, Savannah R.; Tinsley, Caleb; Arslanian, Andrew J.; Dearden, David V. J. Phys. Chem. A 2022, 126, 2950-2958. DOI: 10.1021/acs.jpca.2c01703.

“Multi-CRAFTI: Relative Collision Cross Sections from Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Line Width Measurements,” Pope, Brigham L.; Joaquin, Daniel; Hickey, Jacob T.; Mismash, Noah; Heravi, Tina; Shrestha, Jamir; Arslanian, Andrew J.; Anupriya; Mortensen, Daniel N.; Dearden, David V. J. Am. Soc. Mass Spectrom. 2022, 33, 131- 140. DOI: 10.1021/jasms.1c00297.

“Halide Size-Selective Binding by Cucurbit[5]uril-Alkali Cation Complexes in the Gas Phase,” Heravi, Tina; Shen, Jiewen; Johnson, Spencer; Asplund, Matthew C.; Dearden, David V. J. Phys.
Chem. A, 2021, 125, 7803-7812. DOI: 10.1021/acs.jpca.1c05060.

"Quantitative Collision Cross-Sections from FTICR Linewidth Measurments: Improvements in Theory and Experiment,” Anupriya; Gustafson, E.; Mortensen, D. N.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2018, 29, 251-259. doi: 10.1007/s13361-017-1738-4.

 "Quantitative Collision Cross-Sections from FTICR Linewidth Measurments: Improvements in Theory and Experiment," Anupriya; Gustafson, E.; Mortensen, D. N.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2017, in press. doi: 10.1007/s13361-017-1738-4.

"Collision Cross Sections for 20 Protonated Amino Acids: Fourier Transform Ion Cyclotron Resonance and Ion Mobility Results." Anupriya; Jones, C. A.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2016, 27, 1366-1375. doi: 10.1007/s13361-016-1409-x.

"Linewidth Pressure Measurement: a New Technique for High Vacuum Characterization," Jones, C. A.; Dearden, D. V. J. Am. Soc. Mass Spectrom. 2015, 26, 323-329. doi:10.1007/s13361-014-1031-8. 

"Binding of a,w-Alkyldiammonium Ions by Cucurbit[n]urils in the Gas Phase," Yang, F.; Jones, C. A.; Selvapalam, N.; Ko, Y. H.; Kim, K.; Dearden, D. V. Supramol. Chem. 2014, 26, 684-691. 

“Collision Cross Sectional Areas from Analysis of Fourier Transform Ion Cyclotron Resonance Line Width: a New Method for Characterizing Molecular Structure,” Yang, F.; Voelkel, J. E.; Dearden, D. V. Anal. Chem. 2012, 84, 4851-4857.


“Influence of charge repulsion on binding strengths: experimental and computational characterization of mixed alkali metal complexes of decamethylcucurbit[5]uril,” Mortensen, D. N.; Dearden, D. V. Chem. Commun. 2011, 47, 6081-6083.

"Supramolecular Modification of Ion Chemistry: Modulation of Peptide Charge State and Dissociation Behavior through Complexation with Cucurbit[n]uril (n = 5,6) or Alpha- Cyclodextrin,” Zhang, H.; Grabenauer, M.; Bowers, M. T.; Dearden, D. V. J. Phys. Chem. A 2009, 113, 1508-1517.

“One Ring to Bind Them All: Shape-Selective Complexation of Phenylenediamine Isomers with Cucurbit[6]uril in the Gas Phase,” Dearden, D. V.; Ferrell, T. A.; Asplund, M. C.; Zilch, L. W.; Julian, R. R.; Jarrold, M. F. J. Phys. Chem. A 2009, 113, 989-997.

 

 

See complete publication list