Paul B. Savage

Office: C404A BNSN
Office Phone: 801-422-4020
Lab Phone: 801-422-4172
Email: pbsavage@chem.byu.edu
Office Hours

Education:

BS, Brigham Young University (1988)

Ph.D., The University of Wisconsin (1993)

Postdoctoral Research, Ohio State University (1993-1995)

Curriculum Vitae

Research:

Savage Research Lab has two main areas of study: membrane active antibiotics and glycolipid immunology.

The Savage Lab has developed small-molecule mimics of antimicrobial peptides and is working to understand better mechanisms of antibacterial activity, optimize medical device coatings containing these mimics to prevent bacterial colonization, and optimizing compound structures for varied applications.

Savage researchers also work with immunostimulatory glycolipids and oligosaccharide vaccines.

Publications:

Wnorowska, U.; Piktel, E.; Duptula, P.; Wollny, T.; Krol, G.; Gluszek, K.; Durnas, B.; Pogoda, K; Savage, P. B.; Bucki, R.Sci. Reports2022, 12, 19164. Ceragenin CSA‐13 displays high antibacterial efficiency in a mouse model of urinary tract infection.
Dao, A.; McDonald, M. M.; Savage, P. B.; Little, D. G.; Schindeler, A.J. Bone Oncol.2022, 37, 100460. Preventing osteolytic lesions and osteomyelitis in multiple myeloma.
Oyardi, O.; Savage, P. B.; Guzel, C. B.Pathogens2022, 11, 1044. Effects of ceragenins and antimicrobial peptides on the A549 cell line and in vitro co-culture model of A549 cells and Pseudomonas aeruginosa.
Paprocka, P.; Mankowska, A.; Sklodowski, K.; Krol, G.; Wollny, T.; Lesaik, A.; Gluszek, K.; Savage, P. B.; Durnas, B.; Bucki, R.Pathogens2022, 11, 621. Bactericidal activity of ceragenin in combination with ceftazidime, levofloxacin, co-trimoxazole, and colistin against the opportunistic pathogen Stenotrophomonas maltophilia.
Tokujuk, J.; Deptula, P.; Chmielewska, S. J.; Sklodowski, K.; Mierzejewska, Z. A.; Gradzka-Dahlke, M; Tolstoj, A.; Daniluk, T.; Paprocka, P.; Savage, P. B.; Bucki, R.Pathogens2022, 11, 491. Ceragenin CSA-44 as a means to control the formation of the biofilm on the surface of tooth and composite fillings.
Demir, E. S.; Oyardi, O.; Savage, P. B.; Altay, H. O.; Bozkurt-Guzel, C.J. Antibiot.2022, 75, 403-409. In vitro activity of ceragenins against Burkholderia cepacia complex
Mitchell, G.; Silvis, M. R.; Talkington, K. C.; Budzik, J. M.; Dodd, C. E.; Paluba, J. M.; Oki, E. A.; Trotta, K. L.; Licht, D. J.; Jimenez-Morales, D.; Chou, S.; Savage, P. B.; Gross, C. A.; Marletta, M. A.; Cox, J. S.mBio2022, 13, e02726. Ceragenins and antimicrobial peptides kill bacteria through distinct mechanisms.
Paprocka, P. Durnas, B.; Mankowska, A.; Sklodowski, K.; Krol, G.; Zakrzewska, M.; Czarnowski, M.; Kot, P.; Fortunka, K.; Gozdz, S.; Savage, P. B.; Bucki, R.Infect. Drug Resist.2021, 14, 5681-5698. New b-lactam antibiotics and ceragenins - A study to assess their potential in treatment of infections caused by multidrug-resistant strains of Pseudomonas aeruginosa.
Prasad, S. V.; Piktel, E.; Depcuich, J.; Maximenko, A.; Suprewicz, L.; Daniluk, T.; Spalek, J.; Wnorowska, U.; Zielinski, P. M.; Parlinska-Wojtan, M.; Savage, P. B.; Olka, S.; Fiedoruk, K.; Bucki, R.Nanomedicine2021, 16, 2657-2678. Targeting bacteria causing otitis media using nanosystems containing nonsperical gold nanoparticles and ceragenins.
Skłodowski, K.; Chmielewska, S. J.; Depciuch, J.; Deptuła, P.; Piktel, E.; Daniluk, T.; Zakrzewska, M.; Czarnowski, M.; Cieśluk, M.; Durnaś, B.; Parlinska-Wojtan, M.; Savage, P. B.; Bucki, R.Pharmaceutics2021, 13, 1940. Ceragenin-coated non-spherical gold nanoparticles as novel candidacidal agents.
Piktel, E.;Ościłowska, I.; Łukasz Suprewicz, Ł.; Depciuch, J.; Marcińczyk, N.; Chabielska, E.; Wolak, P.; Głuszek, K.; Klimek, J.; Zieliński, P. M.; Marzec, M. T.; Savage, P. B.; Parlińska-Wojtan, M.; Bucki, R.Cancers, 2021, 13, 5424. Peanut-shaped gold nanoparticles with shell of ceragenin CSA-131 display ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model.
Spałek, J.; Daniluk, T.; Godlewski, A.; Deptuła, P.; Wnorowska, U.; Ziembicka, D.; Cieśluk, M.; Fiedoruk, K.; Ciborowski, M.; Krętowski, A.; Góźdź, S.; Durnaś, B.; Savage, P. B.; Okła, S.;Bucki, R. Pathogens 2021, 10, 1371. Assessment of ceragenins in prevention of damage to voice prostheses caused by Candida biofilm formation.
Kamble, S.; Valtchev, P.; Dao, A.; Pelras, T.; Rogers, M. J.; Savage, P. B.; Dehghani, F.; Schindeler, A.Molecules2021, 26, 1541. Synthesis and characterization of bone binding antibiotic-1 (BBA-1), a novel antimicrobial for orthopedic applications.
Chmielewska, S. J.; Sklodoski, K; Depciuch, J.; Deptula, P.; Piktel, E.; Fiedoruk, K, Kot, P.; Paprocka, P.; Fortunka, K.; Wollny, T.; Wolak, P.; Parlinska-Wojtan, M.; Savage, P. B.; Bucki, R.Pharmaceutics2021, 13, 425. Bactericidal properties of rod-, peanut-, and star-shaped gold nanoparticles coated with ceragenin CSA-131 against multidrug-resistant bacterial strains.
Haynie, T.; Gubler, S.; Drees, C.; Heaton, T.; Mitton, T.; Gleave, Q.; Bendelac, A.; Deng, S.; Savage, P. B.RCS Advances2021, 11, 14357-14361. Synthesis of the pentasaccharide repeating unit from Ruminococcus gnavus and measurement of its inflammatory properties.
Kirshbaum, C.; Greis, K.; Mucha, E.; Kain, S.; Deng, S.; Zappe, A.; Gewinner, S.; Schöllkopf W.; von Helden, G.; Meijer, G.; Savage, P. B.; Marianski, M.; Teyton, L.; Pagel, K.Nat. Comm.2021, 12, 1201. Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy.
Latorre, M. C.; Pérez-Granda, M. J.; Savage, P. G.; Alonso, B.; Martín-Rabadán, P.; Samaniego, R.; Bauzo, E.; Muñoz, P.; Guembe, M.J. Antimicrob. Chemother.2021, 76, 1168-1173. Endotracheal tubes coated with a broad-spectrum antibacterial ceragenin reduce bacterial biofilm in an in vitro bench top model.
Oyardi, Ö, Savage, P. B.; Erturan, Z.; Bozkurt-Guzel, C.J. Antimicrob. Chemother.2021, 76, 443-450. In vitro assessment of CSA-131 and CSA-131 poloxamer form for the treatment of Stenotrophomonas maltophilia infections in cystic fibrosis.
Choi, J.; Mele, T. S.; Porcelli, S. A.; Savage, P. B.; Haeryfar, S. M. M.J. Immunol.2021, 206, 386-397. Harnessing the versatility of iNKT cells in a step-wise approach to sepsis immunotherapy.

See complete list

Awards:

Brigham Young University University Professorship Award, 2020

Brigham Young University Karl G. Maeser Research and Creative Arts Award, 2006
Stoel Rives Utah Innovation Award, Biotechnology, 2006
Brigham Young University Technology Transfer Award, 2005
Brigham Young University Karl G. Maeser Excellence in Teaching Award, 2004
Brigham Young University Creative Works Award, 2001
Brigham Young University Young Scholar Award, 2000
College of Physical and Mathematical Sciences Award for Excellence in Teaching, 1999
National Science Foundation CAREER Award, 1998 - 2002
Student Award for Excellence in Teaching-Department of Chemistry, 1998
Student Award for Excellence in Teaching-Department of Chemistry, 1997