Paul B. Savage

Office: C404A BNSN
Office Phone: 801-422-4020
Lab Phone: 801-422-4172
Email: pbsavage@chem.byu.edu
Office Hours
Education:
BS, Brigham Young University (1988)
Ph.D., The University of Wisconsin (1993)
Postdoctoral Research, Ohio State University (1993-1995)
Research:
Publications:
- Wnorowska, U.; Piktel, E.; Duptula, P.; Wollny, T.; Krol, G.; Gluszek, K.; Durnas, B.; Pogoda, K; Savage, P. B.; Bucki, R.Sci. Reports2022, 12, 19164. Ceragenin CSA‐13 displays high antibacterial efficiency in a mouse model of urinary tract infection.
- Dao, A.; McDonald, M. M.; Savage, P. B.; Little, D. G.; Schindeler, A.J. Bone Oncol.2022, 37, 100460. Preventing osteolytic lesions and osteomyelitis in multiple myeloma.
- Oyardi, O.; Savage, P. B.; Guzel, C. B.Pathogens2022, 11, 1044. Effects of ceragenins and antimicrobial peptides on the A549 cell line and in vitro co-culture model of A549 cells and Pseudomonas aeruginosa.
- Paprocka, P.; Mankowska, A.; Sklodowski, K.; Krol, G.; Wollny, T.; Lesaik, A.; Gluszek, K.; Savage, P. B.; Durnas, B.; Bucki, R.Pathogens2022, 11, 621. Bactericidal activity of ceragenin in combination with ceftazidime, levofloxacin, co-trimoxazole, and colistin against the opportunistic pathogen Stenotrophomonas maltophilia.
- Tokujuk, J.; Deptula, P.; Chmielewska, S. J.; Sklodowski, K.; Mierzejewska, Z. A.; Gradzka-Dahlke, M; Tolstoj, A.; Daniluk, T.; Paprocka, P.; Savage, P. B.; Bucki, R.Pathogens2022, 11, 491. Ceragenin CSA-44 as a means to control the formation of the biofilm on the surface of tooth and composite fillings.
- Demir, E. S.; Oyardi, O.; Savage, P. B.; Altay, H. O.; Bozkurt-Guzel, C.J. Antibiot.2022, 75, 403-409. In vitro activity of ceragenins against Burkholderia cepacia complex
- Mitchell, G.; Silvis, M. R.; Talkington, K. C.; Budzik, J. M.; Dodd, C. E.; Paluba, J. M.; Oki, E. A.; Trotta, K. L.; Licht, D. J.; Jimenez-Morales, D.; Chou, S.; Savage, P. B.; Gross, C. A.; Marletta, M. A.; Cox, J. S.mBio2022, 13, e02726. Ceragenins and antimicrobial peptides kill bacteria through distinct mechanisms.
- Paprocka, P. Durnas, B.; Mankowska, A.; Sklodowski, K.; Krol, G.; Zakrzewska, M.; Czarnowski, M.; Kot, P.; Fortunka, K.; Gozdz, S.; Savage, P. B.; Bucki, R.Infect. Drug Resist.2021, 14, 5681-5698. New b-lactam antibiotics and ceragenins - A study to assess their potential in treatment of infections caused by multidrug-resistant strains of Pseudomonas aeruginosa.
- Prasad, S. V.; Piktel, E.; Depcuich, J.; Maximenko, A.; Suprewicz, L.; Daniluk, T.; Spalek, J.; Wnorowska, U.; Zielinski, P. M.; Parlinska-Wojtan, M.; Savage, P. B.; Olka, S.; Fiedoruk, K.; Bucki, R.Nanomedicine2021, 16, 2657-2678. Targeting bacteria causing otitis media using nanosystems containing nonsperical gold nanoparticles and ceragenins.
- Skłodowski, K.; Chmielewska, S. J.; Depciuch, J.; Deptuła, P.; Piktel, E.; Daniluk, T.; Zakrzewska, M.; Czarnowski, M.; Cieśluk, M.; Durnaś, B.; Parlinska-Wojtan, M.; Savage, P. B.; Bucki, R.Pharmaceutics2021, 13, 1940. Ceragenin-coated non-spherical gold nanoparticles as novel candidacidal agents.
- Piktel, E.;Ościłowska, I.; Łukasz Suprewicz, Ł.; Depciuch, J.; Marcińczyk, N.; Chabielska, E.; Wolak, P.; Głuszek, K.; Klimek, J.; Zieliński, P. M.; Marzec, M. T.; Savage, P. B.; Parlińska-Wojtan, M.; Bucki, R.Cancers, 2021, 13, 5424. Peanut-shaped gold nanoparticles with shell of ceragenin CSA-131 display ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model.
- Spałek, J.; Daniluk, T.; Godlewski, A.; Deptuła, P.; Wnorowska, U.; Ziembicka, D.; Cieśluk, M.; Fiedoruk, K.; Ciborowski, M.; Krętowski, A.; Góźdź, S.; Durnaś, B.; Savage, P. B.; Okła, S.;Bucki, R. Pathogens 2021, 10, 1371. Assessment of ceragenins in prevention of damage to voice prostheses caused by Candida biofilm formation.
- Kamble, S.; Valtchev, P.; Dao, A.; Pelras, T.; Rogers, M. J.; Savage, P. B.; Dehghani, F.; Schindeler, A.Molecules2021, 26, 1541. Synthesis and characterization of bone binding antibiotic-1 (BBA-1), a novel antimicrobial for orthopedic applications.
- Chmielewska, S. J.; Sklodoski, K; Depciuch, J.; Deptula, P.; Piktel, E.; Fiedoruk, K, Kot, P.; Paprocka, P.; Fortunka, K.; Wollny, T.; Wolak, P.; Parlinska-Wojtan, M.; Savage, P. B.; Bucki, R.Pharmaceutics2021, 13, 425. Bactericidal properties of rod-, peanut-, and star-shaped gold nanoparticles coated with ceragenin CSA-131 against multidrug-resistant bacterial strains.
- Haynie, T.; Gubler, S.; Drees, C.; Heaton, T.; Mitton, T.; Gleave, Q.; Bendelac, A.; Deng, S.; Savage, P. B.RCS Advances2021, 11, 14357-14361. Synthesis of the pentasaccharide repeating unit from Ruminococcus gnavus and measurement of its inflammatory properties.
- Kirshbaum, C.; Greis, K.; Mucha, E.; Kain, S.; Deng, S.; Zappe, A.; Gewinner, S.; Schöllkopf W.; von Helden, G.; Meijer, G.; Savage, P. B.; Marianski, M.; Teyton, L.; Pagel, K.Nat. Comm.2021, 12, 1201. Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy.
- Latorre, M. C.; Pérez-Granda, M. J.; Savage, P. G.; Alonso, B.; Martín-Rabadán, P.; Samaniego, R.; Bauzo, E.; Muñoz, P.; Guembe, M.J. Antimicrob. Chemother.2021, 76, 1168-1173. Endotracheal tubes coated with a broad-spectrum antibacterial ceragenin reduce bacterial biofilm in an in vitro bench top model.
- Oyardi, Ö, Savage, P. B.; Erturan, Z.; Bozkurt-Guzel, C.J. Antimicrob. Chemother.2021, 76, 443-450. In vitro assessment of CSA-131 and CSA-131 poloxamer form for the treatment of Stenotrophomonas maltophilia infections in cystic fibrosis.
- Choi, J.; Mele, T. S.; Porcelli, S. A.; Savage, P. B.; Haeryfar, S. M. M.J. Immunol.2021, 206, 386-397. Harnessing the versatility of iNKT cells in a step-wise approach to sepsis immunotherapy.
Awards:
- Brigham Young University University Professorship Award, 2020
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Brigham Young University Karl G. Maeser Research and Creative Arts Award, 2006
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Stoel Rives Utah Innovation Award, Biotechnology, 2006
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Brigham Young University Technology Transfer Award, 2005
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Brigham Young University Karl G. Maeser Excellence in Teaching Award, 2004
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Brigham Young University Creative Works Award, 2001
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Brigham Young University Young Scholar Award, 2000
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College of Physical and Mathematical Sciences Award for Excellence in Teaching, 1999
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National Science Foundation CAREER Award, 1998 - 2002
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Student Award for Excellence in Teaching-Department of Chemistry, 1998
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Student Award for Excellence in Teaching-Department of Chemistry, 1997