Chemistry and Biochemistry

Steven L. Castle

Steven Castle

Office: C411 BNSN
Office Phone: 801-422-1780
Lab Room: C449, C455, C471, C494 and C437A
Lab Phone: 801-422-3827
Email: scastle@chem.byu.edu
Office Hours

Education:

BS, Brigham Young University (1995)

Ph.D., The Scripps Research Institute (2000)

NIH Postdoctoral Fellow, UC Irvine (2000-2002)

Curriculum Vitae

Research:

Castle Research Group

Our research is focused on the total synthesis of architecturally complex bioactive natural products and peptides.  We believe that the structures of such compounds can serve as inspiration for the invention of new organic reactions and processes.  Additionally, studies of their biological activity can increase our understanding of their modes of action, potentially leading to the design and development of new therapeutic agents.  Some of our recent synthetic targets are shown below.

Additional research areas: Bioorganic, Cancer Research, Medicinal and Natural Products

Publications:

61. Joaquin, D.; Lee, M. A.; Kastner, D. W.; Singh, J.; Morrill, S. T.; Damstedt, G.; Castle, S. L.* “Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310-Helical Peptides.” J. Org. Chem. 2020, 85, 1601–1613.

58. Jackman, M. M.; Im, S.; Bohman, S. R.; Lo, C. C. L.; Garrity, A. L.; Castle, S. L.* “Synthesis of Functionalized Nitriles via Microwave-Promoted Fragmentations of Cyclic Iminyl Radicals.” Chem.–Eur. J. 2018, 24, 594–598.

57. Jalan, A.; Kastner, D. W.; Webber, K. G. I.; Smith, M. S.; Price, J. L.;* Castle, S. L.* “Bulky Dehydroamino Acids Enhance Proteolytic Stability and Folding in β-Hairpin Peptides.” Org. Lett. 2017, 19, 5190–5193.

51. Cai, Y.; Jalan, A.; Kubosumi, A. R.; Castle, S. L.* “Microwave-Promoted Tin-Free Iminyl Radical Cyclization with TEMPO Trapping: A Practical Synthesis of 2-Acylpyrroles.” Org. Lett. 2015, 17, 488–491.

36. Ma, B.; Banerjee, B.; Litvinov, D. N.; He, L.; Castle, S. L.* “Total Synthesis of the Antimitotic Bicyclic Peptide Celogentin C.” J. Am. Chem. Soc. 2010, 132, 1159–1171.
 

see complete publication list

Awards:

Associate Director, Simmons Center for Cancer Research

 The Castle Group 2020

(L to R): Courtney Dawes, Joseph Chanthakhoun, Alexander Ramos, Daniel
Joaquin, Garrison Nickel, Diego Moya, Sam Mansfield, Steven Castle,
Austin LeSueur, Taylor Talentino, Collan Moore, Dakota Jones, Michael
Lee, Concordia Lo, Jatinder Singh, Tanner Nelson, Jaden Barfuss