Chemistry and Biochemistry



Organic chemists are interested in organic molecules of many different types. They may synthesize these compounds in the laboratory or isolate them from natural sources. Many of the molecules that organic chemists study play important roles in biology and medicine.

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Merritt B. Andrus


Andrus Lab Group Efforts in our lab are focused on methods for the synthesis of biologically active natural products that possess unique structures and potential for combinatorial library construction and screening. New methods include metal catalyzed couplings and condensations to assemble key intermediates. Libraries of structural variants are then made and used to probe receptor binding and improve activity. Recent ...

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Steven L. Castle


Castle Research Group Our research is focused on the total synthesis of architecturally complex bioactive natural products and peptides.  We believe that the structures of such compounds can serve as inspiration for the invention of new organic reactions and processes.  Additionally, studies of their biological activity can increase our understanding of their modes of action, potentially leading to the design and development ...

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Daniel H. Ess


My group uses and develops computational chemistry tools to discover reaction mechanisms, reactivity principles, and design catalysts that are experimentally realized.   1. Computational catalyst design with industrial application Theory and computation are most powerful when making experimental predictions. The development of accurate quantum mechanical tools enables prediction of molecular catalysts, but there are limited cases of genuine prediction followed ...

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David J. Michaelis


Michaelis Research Group  A multidisciplinary approach to science can enable advances not only at the interface of two fields, but also within strictly disciplinary research. This capacity derives from an acquired understanding of the scientific approach, methods, and techniques used in other disciplines to solve problems.  I intend to establish a research program that employs tools and techniques from other disciplines to ...

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Matt A. Peterson


Research in our group focuses on the chemical synthesis and biological evaluation of potential antitumor and/or antiviral compounds. Modification of naturally occurring nucleosides is a unifying feature in our research. Current interests can be broken down into three areas: (1) Synthesis and evaluation of nucleoside-based enediynes (e.g., uracil-fused and uracil-linked enediynes I and II; and adenosine mimic III); (2) Synthesis and evaluation of transition-state ...

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Joshua L. Price


Price Research Lab Research interests include: Bioorganic chemistry Protein folding and structure The structural and energetic effects of protein glycosylation Design of novel proteins using unnatural amino acids

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Paul B. Savage


Savage Research Lab Membrane active antibiotics Glycolipid immunology Our research is primarily in two areas.  We have developed small-molecule mimics of antimicrobial peptides, and we are working to understand better their mechanism of antibacterial activity, optimize medical device coatings containing these mimics to prevent bacterial colonization, and optimizing compound structures for varied applications.  We also work with immunostimulatory glycolipids and ...

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